SMAD7 antibody

GeneTex

MADH7 antibody

9

This antibody is specific for the human SMAD7 protein and does not cross-react with the human SMAD1, SMAD2, SMAD3, SMAD4, or SMAD5 proteins.

WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-Fr: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Polyclonal

0.34 mg/ml

Unconjugated

SMAD7

SMAD family member 7

CRCS3; hSMAD7; MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 8; MADH7; MADH8; mothers against decapentaplegic homolog 7; Mothers against decapentaplegic, drosophila, homolog of, 7; mothers against DPP homolog 8; SMAD, mothers against DPP homolog 7

Rabbit

IgG

Mothers against decapentaplegic homolog 7

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203