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GTX133996 WB Image
GTX133996 WB Image
GTX133996 WB Image

MDM2 (phospho Ser166) antibody

Research Use Only
GTX133996
GeneTex
Product group Antibodies
Price on request
Packing Size
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Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    MDM2 (phospho Ser166) antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.77 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203