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MFN2 antibody [N1N2], N-term

GTX102055
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetMFN2
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Overview

  • Supplier
    GeneTex
  • Product Name
    MFN2 antibody [N1N2], N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9927
  • Target name
    MFN2
  • Target description
    mitofusin 2
  • Target synonyms
    CMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, HMSN6A, HSG, MARF, MSL, mitofusin-2, hyperplasia suppressor, mitochondrial assembly regulatory factor, transmembrane GTPase MFN2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO95140
  • Protein Name
    Mitofusin-2
  • Scientific Description
    This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Sakiyama H, Li L, Kuwahara-Otani S, et al. A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue. Mol Cell Biochem. 2021,476(10):3577-3590. doi: 10.1007/s11010-021-04178-2
    Read this paper
  • Lam HYP, Chen CC, Chen TT, et al. Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain. Parasitol Int. 2021,80:102231. doi: 10.1016/j.parint.2020.102231
    Read this paper
  • Liu YH, Weng YP, Tsai HY, et al. Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Phytomedicine. 2018,46:184-192. doi: 10.1016/j.phymed.2018.03.037
    Read this paper
  • Wu LH, Chang HC, Ting PC, et al. Laminar shear stress promotes mitochondrial homeostasis in endothelial cells. J Cell Physiol. 2018,233(6):5058-5069. doi: 10.1002/jcp.26375
    Read this paper
  • Li CJ, Chen PK, Sun LY, et al. Enhancement of Mitochondrial Transfer by Antioxidants in Human Mesenchymal Stem Cells. Oxid Med Cell Longev. 2017,2017:8510805. doi: 10.1155/2017/8510805
    Read this paper
  • Cheng CT, Kuo CY, Ouyang C, et al. Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells. Cancer Res. 2016,76(17):5006-18. doi: 10.1158/0008-5472.CAN-15-2921
    Read this paper