ProductsBack/MLH1 antibody [G168-728]

MLH1 antibody [G168-728]

Name: MLH1 antibody [G168-728]
SKU: GTX01744_G10
Availability: BackOrder

GTX01744

ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetMLH1

Overview

Supplier
GeneTex
Product Name
MLH1 antibody [G168-728]
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1:25-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
G168-728
Conjugate
Unconjugated
Gene ID4292
Target name
MLH1
Target description
mutL homolog 1
Target synonyms
COCA2; DNA mismatch repair protein Mlh1; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1; mutL homolog 1, colon cancer, nonpolyposis type 2
Host
Mouse
Isotype
IgG1
Protein IDP40692
Protein Name
DNA mismatch repair protein Mlh1
Scientific Description
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement. Munakata K et al., 2019 Dec, Clin Transl Gastroenterol
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Screening for microsatellite instability in colorectal carcinoma: Practical utility of immunohistochemistry and PCR with fragment analysis in a diagnostic histopathology setting. Cheah PL et al., 2019 Aug, Malays J Pathol
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Granular dot-like staining with MLH1 immunohistochemistry is a clone-dependent artefact. Dasgupta S et al., 2020 Jan, Pathol Res Pract
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Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer. Ackermann A et al., 2019, PLoS One
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Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Saydam N et al., 2007, Nucleic Acids Res
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