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ProductsBack/MLH1 antibody [G168-728]

MLH1 antibody [G168-728]

Research Use Only
GTX01744
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHamster, Human, Mouse, Rat
TargetMLH1
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Overview

  • Supplier
    GeneTex
  • Product Name
    MLH1 antibody [G168-728]
  • Delivery Days Customer
    9
  • Application Supplier Note
    IHC-P: 1:25-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    G168-728
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID4292
  • Target name
    MLH1
  • Target description
    mutL homolog 1
  • Target synonyms
    COCA2; DNA mismatch repair protein Mlh1; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1; mutL homolog 1, colon cancer, nonpolyposis type 2
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP40692
  • Protein Name
    DNA mismatch repair protein Mlh1
  • Scientific Description
    The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
  • Reactivity
    Hamster, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement. Munakata K et al., 2019 Dec, Clin Transl Gastroenterol
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  • Screening for microsatellite instability in colorectal carcinoma: Practical utility of immunohistochemistry and PCR with fragment analysis in a diagnostic histopathology setting. Cheah PL et al., 2019 Aug, Malays J Pathol
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  • Granular dot-like staining with MLH1 immunohistochemistry is a clone-dependent artefact. Dasgupta S et al., 2020 Jan, Pathol Res Pract
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  • Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer. Ackermann A et al., 2019, PLoS One
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  • Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Saydam N et al., 2007, Nucleic Acids Res
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