
WB analysis of various sample lysates using GTX55707 MMP13 antibody. Dilution : 1:1000 Loading : 25μg per lane
MMP13 antibody
GTX55707
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetMMP13
Overview
- SupplierGeneTex
- Product NameMMP13 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4322
- Target nameMMP13
- Target descriptionmatrix metallopeptidase 13
- Target synonymsCLG3, MANDP1, MDST, MMP-13, collagenase 3, matrix metalloproteinase 13 (collagenase 3)
- HostRabbit
- IsotypeIgG
- Protein IDP45452
- Protein NameCollagenase 3
- Scientific DescriptionThis gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Sun Q, Tian FM, Liu F, et al. Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats. Arthritis Res Ther. 2021,23(1):152. doi: 10.1186/s13075-021-02525-8Read this paper



![Various tissue extracts (50 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with MMP13 antibody [HL3067] (GTX640513) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.](https://www.genetex.com/upload/website/prouct_img/normal/GTX640513/GTX640513_T-45446_20240628_WB_M_tissue_24070822_286.webp)


![IHC-P analysis of formalin fixed human placenta tissue using GTX52479 MMP13 antibody [12E10]. Proteinase K pretreatment is required.](https://www.genetex.com/upload/website/prouct_img/normal/GTX52479/GTX52479_20191119_IHC-P_w_23060900_570.webp)