MMP13 antibody [N3C1], Internal
GTX100665
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMMP13
Overview
- SupplierGeneTex
- Product NameMMP13 antibody [N3C1], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.56 mg/ml
- ConjugateUnconjugated
- Gene ID4322
- Target nameMMP13
- Target descriptionmatrix metallopeptidase 13
- Target synonymsCLG3; collagenase 3; MANDP1; matrix metalloproteinase 13 (collagenase 3); MDST; MMP-13
- HostRabbit
- IsotypeIgG
- Protein IDP45452
- Protein NameCollagenase 3
- Scientific DescriptionProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development.Read more
- Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for Osteoarthritis.Read more
- FOXO3-Activated circFGFBP1 Inhibits Extracellular Matrix Degradation and Nucleus Pulposus Cell Death via miR-9-5p/BMP2 Axis in Intervertebral Disc Degeneration In Vivo and In Vitro.Read more
- Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis model.Read more
- Celastrol ameliorates osteoarthritis via regulating TLR2/NF-kappaB signaling pathway.Read more
- Cutaneous Regeneration Mechanism of beta-Sheet Silk Fibroin in a Rat Burn Wound Healing Model. Chou KC et al., 2021 Oct 14, Polymers (Basel)Read more
- PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Yen YT et al., 2021 Jun 2, Commun BiolRead more
- Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p. Zhang L et al., 2021 Jun, Cell CycleRead more
- Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expression. Wang SW et al., 2021 May, J Cell PhysiolRead more
- Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice. Shao LT et al., 2020 Oct, Bone Joint ResRead more