MMP2 antibody [8B4]

GeneTex

MMP2 antibody [8B4]

9

WB: 1 - 2 microg/ml. ICC/IF: 1:10 - 1:500. IHC-P: 2 microg/ml. IHC-Fr: 2 microg/ml. IP: 1 - 2microg /100 - 500microg protein. ELISA: 0.03 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

8B4

1 mg/ml

Unconjugated

MMP2

matrix metallopeptidase 2

CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, 72 kDa type IV collagenase, collagenase type IV-A, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), matrix metalloproteinase-2, matrix metalloproteinase-II, neutrophil gelatinase

Mouse

IgG1

72 kDa type IV collagenase

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

-20°C or -80°C,2°C to 8°C

12352203