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ProductsBack/MMP9 Antibody / Matrix metalloproteinase-9

MMP9 Antibody / Matrix metalloproteinase-9

Research Use Only
ORB606450
Biorbyt
ApplicationsImmunoHistoChemistry
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Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    Biorbyt
  • Product Name
    MMP9 Antibody / Matrix metalloproteinase-9
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P
  • Certification
    Research Use Only
  • Clone ID
    MMP9/2025R
  • Isotype
    IgG
  • Scientific Description
    The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP1 expression.
  • UNSPSC
    12352203