MRL-871 [1392809-08-3]

MedChem Express

MRL-871 [1392809-08-3]

10

1392809-08-3

Research Use Only

99.11

C22H12ClF3N2O3

444.79

MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor gammat (RORgammat) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

O=C(C1=CC=C(C=C1)C2=NN(C3=C2C=CC=C3)C(C4=C(C=CC=C4Cl)C(F)(F)F)=O)O

-20°C,2°C to 8°C

12352200