MRL871

Biorbyt

MRL871

10

1392809-08-3

Research Use Only

C22H12ClF3N2O3

444.794

MRL-871 (MRL871) is a potent, selective inhibitor of RORgammat via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM; significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.

C(O)(=O)C1=CC=C(C2C3=C(N(C(=O)C4=C(C(F)(F)F)C=CC=C4Cl)N=2)C=CC=C3)C=C1

12352200