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MRP1 antibody [N1N2], N-term

Research Use Only
GTX116046
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetABCC1
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Overview

  • Supplier
    GeneTex
  • Product Name
    MRP1 antibody [N1N2], N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.22 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID4363
  • Target name
    ABCC1
  • Target description
    ATP binding cassette subfamily C member 1
  • Target synonyms
    ABC29; ABCC; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; DFNA77; glutathione S-conjugate export pump; glutathione-S-conjugate-translocating ATPase ABCC1; GS-X; leukotriene C(4) transporter; LTC4 transporter; MRP; MRP1; multidrug resistance-associated protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP33527
  • Protein Name
    Multidrug resistance-associated protein 1
  • Scientific Description
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells. Onuma S et al., 2021 May 12, Cells
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  • USP24 promotes drug resistance during cancer therapy. Wang SA et al., 2021 Sep, Cell Death Differ
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  • Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Lanzillotta C et al., 2021 Jan, Prog Neurobiol
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  • Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Maruhashi R et al., 2019 Sep 24, Sci Rep
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  • Transgelin 2 Promotes Paclitaxel Resistance, Migration, and Invasion of Breast Cancer by Directly Interacting with PTEN and Activating PI3K/Akt/GSK-3beta Pathway. Liu L et al., 2019 Dec, Mol Cancer Ther
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  • Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells. Eguchi H et al., 2018 Oct 11, Sci Rep
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  • Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Maruhashi R et al., 2018 Mar, Biochim Biophys Acta Mol Cell Res
    Read more
  • Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. Lin GL et al., 2017, PLoS One
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  • MEK inhibitor enhances sensitivity to chemotherapeutic drugs in multidrug resistant hepatocellular carcinoma cells. Meng Q et al., 2017 Sep, Oncol Lett
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  • Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Liang X et al., 2017 Mar 28, Br J Cancer
    Read more