MRP1 antibody [N1N2], N-term
GTX116046
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetABCC1
Overview
- SupplierGeneTex
- Product NameMRP1 antibody [N1N2], N-term
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.22 mg/ml
- ConjugateUnconjugated
- Gene ID4363
- Target nameABCC1
- Target descriptionATP binding cassette subfamily C member 1 (ABCC1 blood group)
- Target synonymsABC29, ABCC, DFNA77, GS-X, MRP, MRP1, multidrug resistance-associated protein 1, ATP-binding cassette transporter variant ABCC1delta-ex13&14, ATP-binding cassette transporter variant ABCC1delta-ex25&26, ATP-binding cassette, sub-family C (CFTR/MRP), member 1, LTC4 transporter, glutathione S-conjugate export pump, glutathione-S-conjugate-translocating ATPase ABCC1, leukotriene C(4) transporter
- HostRabbit
- IsotypeIgG
- Protein IDP33527
- Protein NameMultidrug resistance-associated protein 1
- Scientific DescriptionThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Onuma S, Manabe A, Yoshino Y, et al. Upregulation of Chemoresistance by Mg(2+) Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells. Cells. 2021,10(5). doi: 10.3390/cells10051179Read this paper
- Wang SA, Young MJ, Wang YC, et al. USP24 promotes drug resistance during cancer therapy. Cell Death Differ. 2021,28(9):2690-2707. doi: 10.1038/s41418-021-00778-zRead this paper
- Lanzillotta C, Zuliani I, Tramutola A, et al. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2021,196:101892. doi: 10.1016/j.pneurobio.2020.101892Read this paper
- Maruhashi R, Eguchi H, Akizuki R, et al. Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells. Sci Rep. 2019,9(1):13753. doi: 10.1038/s41598-019-50276-zRead this paper
- Liu L, Meng T, Zheng X, et al. Transgelin 2 Promotes Paclitaxel Resistance, Migration, and Invasion of Breast Cancer by Directly Interacting with PTEN and Activating PI3K/Akt/GSK-3β Pathway. Mol Cancer Ther. 2019,18(12):2457-2468. doi: 10.1158/1535-7163.MCT-19-0261Read this paper
- Eguchi H, Akizuki R, Maruhashi R, et al. Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells. Sci Rep. 2018,8(1):15157. doi: 10.1038/s41598-018-33566-wRead this paper
- Maruhashi R, Akizuki R, Sato T, et al. Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Biochim Biophys Acta Mol Cell Res. 2018,1865(3):470-479. doi: 10.1016/j.bbamcr.2017.12.005Read this paper
- Lin GL, Ting HJ, Tseng TC, et al. Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PLoS One. 2017,12(10):e0185625. doi: 10.1371/journal.pone.0185625Read this paper
- Meng Q, He X, Xie G, et al. MEK inhibitor enhances sensitivity to chemotherapeutic drugs in multidrug resistant hepatocellular carcinoma cells. Oncol Lett. 2017,14(3):3089-3095. doi: 10.3892/ol.2017.6494Read this paper
- Liang X, Shi H, Yang L, et al. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. Br J Cancer. 2017,116(7):903-911. doi: 10.1038/bjc.2017.32Read this paper
Datasheet
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