MRP1 antibody [QCRL3]

GeneTex

MRP1 antibody [QCRL3]

9

This antibody detects a 190 kDa transmembrane phosphoglycoprotein overexpressed in various hummation dependent multidrug resistant tumor cell lines. It does not cross react with human MDR1 and MDR3, or mouse MRP gene products.

IHC: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

ImmunoHistoChemistry

Research Use Only

Monoclonal

QCRL3

Unconjugated

ABCC1

ATP binding cassette subfamily C member 1

ABC29; ABCC; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; DFNA77; glutathione S-conjugate export pump; glutathione-S-conjugate-translocating ATPase ABCC1; GS-X; leukotriene C(4) transporter; LTC4 transporter; MRP; MRP1; multidrug resistance-associated protein 1

Mouse

IgG2a

Multidrug resistance-associated protein 1

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Human

2°C to 8°C

12352203