MSH3 antibody [C2C3], C-term

GeneTex

MSH3 antibody [C2C3], C-term

9

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1.79 mg/ml

Unconjugated

MSH3

mutS homolog 3

divergent upstream protein; DNA mismatch repair protein Msh3; DUP; epididymis secretory sperm binding protein; FAP4; hMSH3; mismatch repair protein 1; MRP1

Rabbit

IgG

DNA mismatch repair protein Msh3

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Human

-20°C or -80°C,2°C to 8°C

12352203