Navtemadlin

MedChem Express

Navtemadlin [1352066-68-2]

10

1352066-68-2

Research Use Only

99.61

C28H35Cl2NO5S

568.55

Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC 50 of 0.6 nM. Navtemadlin binds to MDM2 with a K d of 0.045 nM [1] [2] .

O=C(O)C[C@]1(C)C(N([C@H](CS(=O)(C(C)C)=O)C(C)C)[C@H](C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC(Cl)=C3)C1)=O

-20°C,2°C to 8°C

12352200