NDFIP1 Antibody

Cusabio

NDFIP1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

NDFIP1

Nedd4 family interacting protein 1

breast cancer-associated protein SGA-1M; N4WBP5; NEDD4 family-interacting protein 1; Nedd4 WW domain-binding protein 5; putative MAPK-activating protein PM13; putative NF-kappa-B-activating protein 164; putative NFKB and MAPK-activating protein

Rabbit

IgG

NEDD4 family-interacting protein 1

Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Petroziello J.M., Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. Matsuda A., Oncogene 22:3307-3318(2003). Otsuki T., DNA Res. 12:117-126(2005).

Human

-20°C or -80°C

12352203