Necrosulfonamide [1360614-48-7]

AdipoGen Life Sciences

Necrosulfonamide [1360614-48-7]

10

1360614-48-7

Research Use Only

>95%

C18H15N5O6S2

461.5

Chemical. CAS: 1360614-48-7. Formula: C18H15N5O6S2. MW: 461.5. Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3). Shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Potent inhibitor of Gasdermin D that works well for mice studies. It binds directly to Gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis. Displayed neuroprotective effects after ischemic brain injury, prevented cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells and rescued cells from TLR3 ligand-induced death. - Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3). Shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Potent inhibitor of gasdermin D that works well for mice studies. It binds directly to gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis. Displayed neuroprotective effects after ischemic brain injury, prevented cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells and rescued cells from TLR3 ligand-induced death.

O=C(/C=C/C1=CC=C([N+]([O-])=O)S1)NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2

2°C to 8°C,-20°C

12352200