Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

Necrosulfonamide [1360614-48-7]

Research Use Only
AG-CR1-3705
AdipoGen Life Sciences
Estimated Purity>95%
Product group Chemicals
Molecular Weight461.5
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Necrosulfonamide [1360614-48-7]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C18H15N5O6S2
  • Molecular Weight
    461.5
  • Scientific Description
    Chemical. CAS: 1360614-48-7. Formula: C18H15N5O6S2. MW: 461.5. Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3). Shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Potent inhibitor of Gasdermin D that works well for mice studies. It binds directly to Gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis. Displayed neuroprotective effects after ischemic brain injury, prevented cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells and rescued cells from TLR3 ligand-induced death. - Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3). Shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Potent inhibitor of gasdermin D that works well for mice studies. It binds directly to gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis. Displayed neuroprotective effects after ischemic brain injury, prevented cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells and rescued cells from TLR3 ligand-induced death.
  • SMILES
    O=C(/C=C/C1=CC=C([N+]([O-])=O)S1)NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200