CgoaEGY7P_6EPoaoAAAAAAix46w062.png
CgoaEGY7P_6EPoaoAAAAAAix46w062.png
Necrosulfonamide
T6904
CAS Number1360614-48-7
Product group Chemicals
Molecular Weight461.47
Overview
- SupplierTargetMol Chemicals
- Product NameNecrosulfonamide
- Delivery Days Customer4
- CAS Number1360614-48-7
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameNecrosulfonamide
- Molecular FormulaC18H15N5O6S2
- Molecular Weight461.47
- Scientific Description(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
- Shelf life instruction3 years
- SMILESCOC1=C(NS(=O)(=O)C2=CC=C(NC(=O)\C=C\C3=CC=C(S3)[N+]([O-])=O)C=C2)N=CC=N1
- Storage Instruction-20°
- UNSPSC12352200
References
- Yang W, Liu S, Li Y, et al. Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia. Cancer Letters. 2020Read more