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Necrosulfonamide

HY-100573
MedChem Express
CAS Number1360614-48-7
Product group Chemicals
Estimated Purity99.47
Molecular Weight461.47
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Necrosulfonamide [1360614-48-7]
  • Delivery Days Customer
    10
  • CAS Number
    1360614-48-7
  • Estimated Purity
    99.47
  • Molecular Formula
    C18H15N5O6S2
  • Molecular Weight
    461.47
  • Scientific Description
    Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) . Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis [1] .
  • SMILES
    O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200