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Nectin 1 antibody

GTX130824
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetNECTIN1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Nectin 1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.44 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5818
  • Target name
    NECTIN1
  • Target description
    nectin cell adhesion molecule 1
  • Target synonyms
    CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRL1, PVRR, PVRR1, SK-12, nectin-1, nectin-1, ectodermal dysplasia 4 (Margarita Island type), herpes simplex virus type 1 sensitivity, herpes virus entry mediator C, herpesvirus Ig-like receptor, nectin 1, poliovirus receptor-like 1, poliovirus receptor-related 1 (herpesvirus entry mediator C), poliovirus receptor-related protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ15223
  • Protein Name
    Nectin-1
  • Scientific Description
    This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Sheen YS, Lin MH, Tzeng WC, et al. Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1-mediated increase in vascular permeability. J Pathol. 2020,250(4):452-463. doi: 10.1002/path.5393
    Read this paper