Nigericin (Standard) [28380-24-7]

MedChem Express

Nigericin (Standard) [28380-24-7]

5

Research Use Only

Nigericin (Standard) is the analytical standard of Nigericin (HY-127019). This product is intended for research and analytical applications. Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/beta-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7].

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