Niraparib (MK-4827)

Selleck Chemicals

Niraparib (MK-4827) [1038915-60-4]

9

1038915-60-4

Research Use Only

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Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.

-80°C

51202000