NLRP3/AIM2-IN-3

MedChem Express

NLRP3/AIM2-IN-3 [1787787-60-3]

10

1787787-60-3

Research Use Only

98.23

C16H14N2O2

266.29

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis . NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC 50 of 0.077 +/- 0.008 microM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization [1] .

O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3

-20°C,2°C to 8°C

12352200