NLRP3/AIM2-IN-3 [1787787-60-3]
T60442
CAS Number1787787-60-3
Product group Chemicals
Estimated Purity97.16%
Molecular Weight266.29
Overview
- SupplierTargetMol Chemicals
- Product NameNLRP3/AIM2-IN-3 [1787787-60-3]
- Delivery Days Customer4
- CAS Number1787787-60-3
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameNLRP3/AIM2-IN-3
- Estimated Purity97.16%
- Molecular FormulaC16H14N2O2
- Molecular Weight266.29
- Scientific DescriptionNLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 +/- 0.008 micro M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 +/- 0.008 micro M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 +/- 0.008 microM. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC.
- Shelf life instruction3 years
- SMILESOc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1
- Storage Instruction-20°C
- UNSPSC51202000
References
- Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Jiao Y et al., 2022 Mar 15, Eur J Med ChemRead more
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