Bio-Connect

NRF1 antibody

GTX103179
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetNRF1
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Overview

  • Supplier
    GeneTex
  • Product Name
    NRF1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.69 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4899
  • Target name
    NRF1
  • Target description
    nuclear respiratory factor 1
  • Target synonyms
    alpha palindromic-binding protein; ALPHA-PAL; nuclear respiratory factor 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ16656
  • Protein Name
    Nuclear respiratory factor 1
  • Scientific Description
    This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for nuclear factor (erythroid-derived 2)-like 1 which has an official symbol of NFE2L1. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Timely expression of PGAM5 and its cleavage control mitochondrial homeostasis during neurite re-growth after traumatic brain injury.
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  • Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training.
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  • Effects of aging and long-term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats.
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  • mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing Loss via Maintaining TFAM-mtDNA Interaction and Mitochondrial Biogenesis. Chen JW et al., 2022, Front Cell Neurosci
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  • Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults. Mesquita PHC et al., 2020 Aug, Physiol Rep
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  • The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. Ma B et al., 2019 Mar 4, Nat Commun
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  • 1,25-Dihydroxyvitamin D3 modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17beta-estradiol secretion in rat granulosa cells. Lee CT et al., 2019 Jan, J Steroid Biochem Mol Biol
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  • A mitohormetic response to pro-oxidant exposure in the house mouse. Zhang Y et al., 2018 Jan 1, Am J Physiol Regul Integr Comp Physiol
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  • Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia. Chen YH et al., 2016, PLoS One
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  • Rosiglitazone activation of PPARgamma-dependent signaling is neuroprotective in mutant huntingtin expressing cells. Chiang MC et al., 2015 Nov 1, Exp Cell Res
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