NUP98 antibody [2H10]

GeneTex

NUP98 antibody [2H10] - Comparison Validated

9

*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Dot Blot, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Monoclonal

2H10

1 mg/ml

Unconjugated

NUP98

nucleoporin 98 and 96 precursor

ADIR2, NUP196, NUP96, Nup98-96, nuclear pore complex protein Nup98-Nup96, nuclear pore complex protein Nup98, GLFG-repeat containing nucleoporin, NUP98/PHF23 fusion 2 protein, Nup98-Nup96, nucleoporin 96, nucleoporin 98kD, nucleoporin 98kDa

Rat

IgG2c

Nuclear pore complex protein Nup98-Nup96

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

-20°C or -80°C,2°C to 8°C

12352203