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Nutlin-3

Research Use Only
27711
BPS Bioscience
CAS Number548472-68-0
Product group Chemicals
Estimated Purity>98%
Molecular Weight581.5 Da
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    Nutlin-3
  • Delivery Days Customer
    7
  • CAS Number
    548472-68-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C30H30Cl2N4O4
  • Molecular Weight
    581.5 Da
  • Scientific Description
    Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 microM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.
  • UNSPSC
    12352200