Nutlin-3 [548472-68-0]

AbMole BioScience

Nutlin-3 [548472-68-0]

7

548472-68-0

Research Use Only

99.70%

C30H30Cl2N4O4

581.49

Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM. Nutlin-3 induces apoptosis in cancer cells. Nutlin-3 treatment induces the expression of MDM2 and p21, and displays potent antiproliferative activity with IC50 of ~1.5 uM in cells with wild-type p53 such as HCT116, RKO and SJSA-1.

4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

-20°C

12161500