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Chemical Structure
Chemical Structure
Chemical Structure

NVP-BEZ235

AG-CR1-3633
AdipoGen Life Sciences
CAS Number915019-65-7
Product group Chemicals
Estimated Purity>98%
Molecular Weight469.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    NVP-BEZ235
  • Delivery Days Customer
    10
  • CAS Number
    915019-65-7
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C30H23N5O
  • Molecular Weight
    469.5
  • Scientific Description
    Chemical. CAS: 915019-65-7. Formula: C30H23N5O. MW: 469.5. Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays. Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, Enhances the efficacy of other anticancer agents when used in in vivo combination studies. Strongly inhibits VEGF-induced cell proliferation and survival in vitro and VEGF-induced angiogenesis in vivo. Shown to be a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage and DNA double-strand break repair. Shown to have neuroprotective properties on amyloid-beta 1-42 induced neurotoxicity and memory impairment. Shows anti-trypanosomal activity for some selected species. - Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays. Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, Enhances the efficacy of other anticancer agents when used in in vivo combination studies. Strongly inhibits VEGF-induced cell proliferation and survival in vitro and VEGF-induced angiogenesis in vivo. Shown to be a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage and DNA double-strand break repair. Shown to have neuroprotective properties on amyloid-beta 1-42 induced neurotoxicity and memory impairment. Shows anti-trypanosomal activity for some selected species.
  • SMILES
    CN(C1=CN=C(C=CC(C2=CC(C=CC=C3)=C3N=C2)=C4)C4=C1N5C6=CC=C(C(C)(C)C#N)C=C6)C5=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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