O-Demethyl-Gefitinib

Selleck Chemicals

O-Demethyl-Gefitinib

9

Research Use Only

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O-Desmethyl gefitinib, a major active metabolite of gefitinib, is a potent EGFR (ErbB1/HER1) inhibitor, inhibits subcellular EGFR tyrosine kinase through a mechanism similar to that of gefitinib with IC50 values of 36 and 22 nM, respectively.

12352200