Occludin antibody
GTX114949
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetOCLN
Overview
- SupplierGeneTex
- Product NameOccludin antibody
- Delivery Days Customer9
- Antibody SpecificityThe mouse reactivity of this antibody is based on mouse IHC-P testing and may be not suitable for mouse WB assay.
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.25 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID100506658
- Target nameOCLN
- Target descriptionoccludin
- Target synonymsBLCPMG; occludin; phosphatase 1, regulatory subunit 115; PPP1R115; PTORCH1
- HostRabbit
- IsotypeIgG
- Protein IDQ16625
- Protein NameOccludin
- Scientific DescriptionThis gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
- ReactivityHuman, Monkey, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction. Chou HC et al., 2022 Jun 15, J Biomed SciRead more
- S1PR3, as a Core Protein Related to Ischemic Stroke, is Involved in the Regulation of Blood-Brain Barrier Damage. Fan X et al., 2022, Front PharmacolRead more
- Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus. Muranyi W et al., 2022 Jun 17, iScienceRead more
- A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. Wu C et al., 2022 Jan, Free Radic Biol MedRead more
- Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes. Watanabe D et al., 2021 Sep 16, PharmaceuticsRead more
- CircLphn3 protects the blood-brain barrier in traumatic brain injury. Cheng YQ et al., 2022 Apr, Neural Regen ResRead more
- Proneurogenic and neuroprotective effect of a multi strain probiotic mixture in a mouse model of acute inflammation: Involvement of the gut-brain axis. Petrella C et al., 2021 Oct, Pharmacol ResRead more
- Beneficial effects of Dendrobium officinale on metabolic hypertensive rats by triggering the enteric-origin SCFA-GPCR43/41 pathway. Li B et al., 2021 Jun 21, Food FunctRead more
- Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein. Busatto S et al., 2020 Nov 7, J NanobiotechnologyRead more
- Guiqi Baizhu Decoction Alleviates Radiation Inflammation in Rats by Modulating the Composition of the Gut Microbiota. Zhang LY et al., 2020, Evid Based Complement Alternat MedRead more