p53 antibody [B20.1 (BP 53.122)]

GeneTex

p53 antibody [B20.1 (BP 53.122)]

9

This antibody reacts with wild type as well as mutant type of the p53 protein. It recognizes an epitope in the N-terminus of the human p53 protein. This antibody recognizes cell nuclei in which the p53 protein are generally localized. This antibody does n

This antibody can be used on formalin-fixed, paraffin-embedded tissue sections at a dilution of 1:50-1:75 . Heat mediated antigen retrieval is strongly recommended for consistent and reproducible results. For western blotting use at 1:100-1:250.This antibody is not suitable for frozen tissue sections. The optimal conditions should be determined by the individual laboratory.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

B20.1 (BP 53.122)

0.35 mg/ml

Unconjugated

TP53

tumor protein p53

antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; tumor supressor p53

Mouse

IgG2a

Cellular tumor antigen p53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Hamster, Human, Monkey, Mouse, Rat

2°C to 8°C

12352203