Western Blot analysis of 293T cells using p53 Monoclonal Antibody at dilution of 1) 1:1000 2) 1:2000.
Western Blot analysis of 293T cells using p53 Monoclonal Antibody at dilution of 1) 1:1000 2) 1:2000.
p53 Monoclonal Antibody
E-AB-22015
Product group Antibodies
Overview
- SupplierElabscience
- Product Namep53 Monoclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionActs as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
- UNSPSC12352203