Bio-Connect

PAX6 antibody

GTX113241
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPAX6
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    PAX6 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. IP: 1:1000-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5080
  • Target name
    PAX6
  • Target description
    paired box 6
  • Target synonyms
    AN, AN1, AN2, ASGD5, D11S812E, FVH1, MGDA, WAGR, paired box protein Pax-6, Aniridia 1, Aniridia 2, alternative protein PAX6, aniridia type II protein, oculorhombin, paired box 6 PAX6-12a isoform, paired box 6 PAX6A-ASdel6 isoform, paired box 6 PAX6A-ASdel6-AS7 isoform, paired box 6 PAX6A-del6 isoform, paired box 6 PAX6B-ASdel6 isoform, paired box 6 PAX6D isoform, paired box homeotic gene-6
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP26367
  • Protein Name
    Paired box protein Pax-6
  • Scientific Description
    This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peters anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Gilbert-Jaramillo J, Purnama U, Molnár Z, et al. Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy. Biol Open. 2023,12(4). doi: 10.1242/bio.059889
    Read this paper
  • Chen A, Wang M, Xu C, et al. Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation. Front Mol Neurosci. 2023,16:1151162. doi: 10.3389/fnmol.2023.1151162
    Read this paper
  • Fabra-Beser J, Alves Medeiros de Araujo J, Marques-Coelho D, et al. Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation. J Neurosci. 2021,41(33):6969-6986. doi: 10.1523/JNEUROSCI.2905-20.2021
    Read this paper
  • Manganas LN, Durá I, Osenberg S, et al. BASP1 labels neural stem cells in the neurogenic niches of mammalian brain. Sci Rep. 2021,11(1):5546. doi: 10.1038/s41598-021-85129-1
    Read this paper
  • Yang SC, Liu JJ, Wang CK, et al. Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2. FASEB J. 2019,33(9):10577-10592. doi: 10.1096/fj.201800220RR
    Read this paper
  • Xu R, Brawner AT, Li S, et al. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019,24(6):908-926.e8. doi: 10.1016/j.stem.2019.04.014
    Read this paper
  • Zhang Q, Nguyen P, Xu Q, et al. Neural Progenitor-Like Cells Induced from Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration. Stem Cells Transl Med. 2017,6(2):458-470. doi: 10.5966/sctm.2016-0177
    Read this paper
  • Chen C, Jiang P, Xue H, et al. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014,5:4430. doi: 10.1038/ncomms5430
    Read this paper
  • Chang WF, Xu J, Chang CC, et al. SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice. Brain Struct Funct. 2015,220(3):1539-53. doi: 10.1007/s00429-014-0743-7
    Read this paper
  • Chen KC, Hsi E, Hu CY, et al. MicroRNA-328 may influence myopia development by mediating the PAX6 gene. Invest Ophthalmol Vis Sci. 2012,53(6):2732-9. doi: 10.1167/iovs.11-9272
    Read this paper