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ProductsBack/PD-L1 antibody

PD-L1 antibody

GTX104763
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCD274
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Overview

  • Supplier
    GeneTex
  • Product Name
    PD-L1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.97 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID29126
  • Target name
    CD274
  • Target description
    CD274 molecule
  • Target synonyms
    ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1, programmed cell death 1 ligand 1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9NZQ7
  • Protein Name
    Programmed cell death 1 ligand 1
  • Scientific Description
    Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wang BY, Shen HT, Lee YL, et al. Inhibition of Na+/H+ exchanger (NHE) 7 by 5-(N-ethyl-N-isopropyl)-Amiloride displays anti-cancer activity in non-small cell lung cancer by disrupting cancer stem cell activity and downregulating PD-L1 expression. Am J Cancer Res. 2023,13(10):4721-4733.
    Read this paper
  • Wu Y, Zhou L, Zou Y, et al. Disrupting the phase separation of KAT8-IRF1 diminishes PD-L1 expression and promotes antitumor immunity. Nat Cancer. 2023,4(3):382-400. doi: 10.1038/s43018-023-00522-1
    Read this paper
  • Chung SY, Chang YC, Hsu DS, et al. A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer. Neoplasia. 2023,35:100856. doi: 10.1016/j.neo.2022.100856
    Read this paper
  • Chung BS, Liao IC, Lin PC, et al. PD-L1 Expression in High-Risk Early-Stage Colorectal Cancer-Its Clinical and Biological Significance in Immune Microenvironment. Int J Mol Sci. 2022,23(21). doi: 10.3390/ijms232113277
    Read this paper
  • Su KW, Lin HY, Chiu HC, et al. Thyroid Hormone Induces Oral Cancer Growth via the PD-L1-Dependent Signaling Pathway. Cells. 2022,11(19). doi: 10.3390/cells11193050
    Read this paper
  • Hung YH, Lai MD, Hung WC, et al. Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD-L1. Am J Cancer Res. 2022,12(2):713-728.
    Read this paper
  • Omenai SA, Ajani MA, Okolo CA. Programme death ligand 1 expressions as a surrogate for determining immunotherapy in cervical carcinoma patients. PLoS One. 2022,17(2):e0263615. doi: 10.1371/journal.pone.0263615
    Read this paper
  • Lin YZ, Liu SH, Wu WR, et al. miR-4759 suppresses breast cancer through immune checkpoint blockade. Comput Struct Biotechnol J. 2022,20:241-251. doi: 10.1016/j.csbj.2021.12.020
    Read this paper
  • Asrini R, Ham MF, Asmarinah A, et al. Expression of programmed cell death ligand-1 protein in germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma. Mol Clin Oncol. 2022,16(2):42. doi: 10.3892/mco.2021.2474
    Read this paper
  • Li L, Jin XJ, Li JW, et al. Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer. Cancer Sci. 2021,112(5):1772-1784. doi: 10.1111/cas.14851
    Read this paper

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