PD-L2 Antibody / Programmed death ligand 2 / CD273
ORB640005
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
Overview
- SupplierBiorbyt
- Product NamePD-L2 Antibody / Programmed death ligand 2 / CD273
- Delivery Days Customer16
- Application Supplier NoteOptimal dilution of the antibody should be determined by the researcher.
- ApplicationsFlow Cytometry
- Applications SupplierFlow cytometry: 1-2ug/million cells in 0.1ml FACS
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDPDL2/1850
- ConjugateUnconjugated
- HostMouse
- IsotypeIgG1
- Scientific DescriptionRecognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203