Bio-Connect

PD-L2 Antibody / Programmed death ligand 2 / CD273

Research Use Only
ORB640005
Biorbyt
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    PD-L2 Antibody / Programmed death ligand 2 / CD273
  • Delivery Days Customer
    16
  • Application Supplier Note
    Optimal dilution of the antibody should be determined by the researcher.
  • Applications
    Flow Cytometry
  • Applications Supplier
    Flow cytometry: 1-2ug/million cells in 0.1ml FACS
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    PDL2/1850
  • Conjugate
    Unconjugated
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203