ProductsBack/PDE10A antibody [C2C3], C-term

PDE10A antibody [C2C3], C-term

Name: PDE10A antibody [C2C3], C-term
SKU: GTX118886_G10
Availability: BackOrder

GTX118886

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetPDE10A

Overview

Supplier
GeneTex
Product Name
PDE10A antibody [C2C3], C-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.1 mg/ml
Conjugate
Unconjugated
Gene ID10846
Target name
PDE10A
Target description
phosphodiesterase 10A
Target synonyms
ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 3',5' cAMP/cGMP phosphodiesterase, dJ416F21.1 (phosphodiesterase 10A), phosphodiesterase 10A1 (PDE10A1), phosphodiesterase 10A7 (PDE10A7)
Host
Rabbit
Isotype
IgG
Protein IDQ9Y233
Protein Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Scientific Description
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate (Fujishige et al., 2000 [PubMed 10998054]).[supplied by OMIM]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Lee KJ, Chang WL, Chen X, et al. Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin. Cancer Prev Res (Phila). 2021,14(11):995-1008. doi: 10.1158/1940-6207.CAPR-21-0208
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Fusco JP, Pita G, Pajares MJ, et al. Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced lung cancer. Cancer Med. 2018,7(7):3474-3483. doi: 10.1002/cam4.1500
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Li N, Chen X, Zhu B, et al. Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10. Oncotarget. 2015,6(29):27403-15. doi: 10.18632/oncotarget.4741
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Li N, Lee K, Xi Y, et al. Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity. Oncogene. 2015,34(12):1499-509. doi: 10.1038/onc.2014.94
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