PerCP/Cyanine5.5 Anti-Human CD28 Antibody

Reddot Biotech

PerCP/Cyanine5.5 Anti-Human CD28 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

CD28.2

Double Conjugated

CD28

CD28 molecule

T-cell-specific surface glycoprotein CD28; Tp44

Mouse

IgG1

CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

Human

2°C to 8°C

12352203