IHC-P analysis of human follicular lymphoma using GTX01949 Perforin antibody [5B10]. Note focal granular staining of occasional cytotoxic T lymphocytes.
IHC-P analysis of human follicular lymphoma using GTX01949 Perforin antibody [5B10]. Note focal granular staining of occasional cytotoxic T lymphocytes.
Perforin antibody [5B10]
GTX01949
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetPRF1
Overview
- SupplierGeneTex
- Product NamePerforin antibody [5B10]
- Delivery Days Customer9
- Antibody SpecificityThis antibofy shows cross-reactivity with smooth muscle and differentiated epithelium.
- Application Supplier NoteIHC-P: 1:20. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5B10
- ConjugateUnconjugated
- Gene ID5551
- Target namePRF1
- Target descriptionperforin 1
- Target synonymscytolysin; HPLH2; lymphocyte pore-forming protein; P1; perforin 1 (pore forming protein); perforin-1; PFP
- HostMouse
- IsotypeIgG1
- Protein IDP14222
- Protein NamePerforin-1
- Scientific DescriptionThis gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203