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ProductsBack/PF-562271 [717907-75-0]

PF-562271 [717907-75-0]

Research Use Only
SYN-1064
SYNkinase
CAS Number717907-75-0
Product group Chemicals
Estimated Purity>95%
Molecular Weight507.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    PF-562271 [717907-75-0]
  • Delivery Days Customer
    10
  • CAS Number
    717907-75-0
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C21H20F3N7O3S
  • Molecular Weight
    507.5
  • Scientific Description
    Chemical. CAS: 717907-75-0. Formula: C21H20F3N7O3S. MW: 507.5. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections. - PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000