Immunohistochemical analysis of paraffin-embedded human brain tissue using MAP3K8 (Phospho-Ser400) antibody (left)or the same antibody preincubated with blocking peptide (right).
Immunohistochemical analysis of paraffin-embedded human brain tissue using MAP3K8 (Phospho-Ser400) antibody (left)or the same antibody preincubated with blocking peptide (right).
Phospho-MAP3K8 (Ser400) Antibody
CSB-PA588716
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetMAP3K8
Overview
- SupplierCusabio
- Product NamePhospho-MAP3K8 (Ser400) Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1326
- Target nameMAP3K8
- Target descriptionmitogen-activated protein kinase kinase kinase 8
- Target synonymsaugmented in rheumatoid arthritis 2; AURA2; c-COT; COT; cot (cancer Osaka thyroid) oncogene; EST; ESTF; Ewing sarcoma transformant; MEKK8; mitogen-activated protein kinase kinase kinase 8; proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; TPL2; Tpl-2; tumor progression locus 2
- HostRabbit
- IsotypeIgG
- Protein IDP41279
- Protein NameMitogen-activated protein kinase kinase kinase 8
- Scientific DescriptionThis gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). Miyoshi J., Mol. Cell. Biol. 11:4088-4096(1991). Aoki M., J. Biol. Chem. 268:22723-22732(1993). Chan A.M.,Oncogene 8:1329-1333(1993).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203