Bio-Connect

PI3 kinase p85 alpha antibody [N2C1], Internal

GTX111068
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPIK3R1
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Overview

  • Supplier
    GeneTex
  • Product Name
    PI3 kinase p85 alpha antibody [N2C1], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.46 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5295
  • Target name
    PIK3R1
  • Target description
    phosphoinositide-3-kinase regulatory subunit 1
  • Target synonyms
    AGM7; GRB1; IMD36; p85; p85-ALPHA; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3K regulatory subunit alpha; PI3-kinase subunit p85-alpha; ptdIns-3-kinase regulatory subunit alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP27986
  • Protein Name
    Phosphatidylinositol 3-kinase regulatory subunit alpha
  • Scientific Description
    Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Sacubitril/valsartan attenuates myocardial inflammation, hypertrophy, and fibrosis in rats with heart failure with preserved ejection fraction.
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  • Systemic Deficiency of PTEN Accelerates Breast Cancer Growth and Metastasis. Chen J et al., 2022, Front Oncol
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  • Phytochemical-rich herbal formula ATG-125 protects against sucrose-induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice. Yeh CC et al., 2022 Feb, Mol Med Rep
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  • Nesfatin-1 facilitates IL-1beta production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-kappaB pathways. Lee KT et al., 2021 Sep 24, Aging (Albany NY)
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  • CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma. Chao CC et al., 2020 Feb 17, Cancers (Basel)
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  • MiR-8-3p regulates hyperthermia-induced lactate secretion by targeting PPP2R5B in boar Sertoli cells. Hu Y et al., 2019 Nov, Mol Reprod Dev
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  • Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats. Huang WY et al., 2018 Aug, Curr Med Sci
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  • The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death. Chen PH et al., 2016, PLoS One
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  • The Synthetic beta-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways. Chiu WC et al., 2016, PLoS One
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