Pirtobrutinib [2101700-15-4]
HY-131328
CAS Number2101700-15-4
Product group Chemicals
Estimated Purity99.88
Molecular Weight479.43
Overview
- SupplierMedChem Express
- Product NamePirtobrutinib [2101700-15-4]
- Delivery Days Customer10
- CAS Number2101700-15-4
- CertificationResearch Use Only
- Estimated Purity99.88
- Molecular FormulaC22H21F4N5O3
- Molecular Weight479.43
- Scientific DescriptionPirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 microM[1].
- SMILESO=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)=CC=C3OC)=O)C=C2)N
- Storage Instruction2°C to 8°C
- UNSPSC12352200
MSDS
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