Pirtobrutinib [2101700-15-4]

TargetMol Chemicals

Pirtobrutinib [2101700-15-4]

4

2101700-15-4

Chemical

Research Use Only

Pirtobrutinib

99.76%

C22H21F4N5O3

479.43

Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 microM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets.

3 years

COc1ccc(F)cc1C(=O)NCc1ccc(cc1)-c1nn([C@@H](C)C(F)(F)F)c(N)c1C(N)=O

-20°C

12352200