PMS2 (N) Antibody, Rabbit Polyclonal

Biorbyt

PMS2 (N) Antibody, Rabbit Polyclonal

16

WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human PMS2.

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

100 ug/ml

Unconjugated

PMS2

PMS1 homolog 2, mismatch repair system component

HNPCC4, LYNCH4, MLH4, MMRCS4, PMS-2, PMS2CL, PMSL2, mismatch repair endonuclease PMS2, DNA mismatch repair protein PMS2, PMS1 homolog 2, mismatch repair protein, PMS1 protein homolog 2, PMS2 postmeiotic segregation increased 2

Rabbit

Mismatch repair endonuclease PMS2

Rabbit polyclonal to PMS2. Mismatch repair endonuclease PMS2 belongs to the DNA mismatch repair MutL/HexB family. PMS2 is a component of the post-replicative DNA mismatch repair system (MMR). PMS2 heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch.

Human, Mouse

-20°C

12352203