Western blot analysis of mouse liver cytosol extract using GTX14824 at a dilution of 1/250. Proteins were visualised using a goat anti-mouse secondary antibody conjugated to HRP and a DAB detection system.
Western blot analysis of mouse liver cytosol extract using GTX14824 at a dilution of 1/250. Proteins were visualised using a goat anti-mouse secondary antibody conjugated to HRP and a DAB detection system.
PPM1A antibody [p6c7]
GTX14824
Overview
- SupplierGeneTex
- Product NamePPM1A antibody [p6c7]
- Delivery Days Customer9
- Application Supplier NoteELISA: Use at an assay dependent dilution. WB: Use at a dilution of 1/250 - 1/1000. Predicted molecular weight: 42 kDa. Optimal dilutions/concentrations should be determined by the end user.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDp6c7
- Concentration0.1 mg/ml
- ConjugateUnconjugated
- Gene ID5494
- Target namePPM1A
- Target descriptionprotein phosphatase, Mg2+/Mn2+ dependent 1A
- Target synonymsPP2CA; PP2Calpha; PP2C-ALPHA; protein phosphatase 1A
- HostMouse
- IsotypeIgG2b
- Protein IDP35813
- Protein NameProtein phosphatase 1A
- Scientific DescriptionThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
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