PPM1F antibody [AT6D11]

GeneTex

PPM1F antibody [AT6D11]

9

The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Western Blot, ELISA

Research Use Only

Monoclonal

AT6D11

1 mg/ml

Unconjugated

PPM1F

protein phosphatase, Mg2+/Mn2+ dependent 1F

Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CAMKP; CaMKPase; FEM-2; hFEM-2; partner of PIX 2; POPX2; PP2C phosphatase; protein fem-2 homolog; protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing)

Mouse

IgG1

Protein phosphatase 1F

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203