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PPP1A antibody

GTX105255
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat, Zebra Fish
TargetPPP1CA
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Overview

  • Supplier
    GeneTex
  • Product Name
    PPP1A antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    Based on sequence homology, this antibody may cross react with PPP1CB or PPP1CC proteins.
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.4 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5499
  • Target name
    PPP1CA
  • Target description
    protein phosphatase 1 catalytic subunit alpha
  • Target synonyms
    PP1A; PP-1A; PP1alpha; PPP1A; protein phosphatase 1, catalytic subunit, alpha isozyme; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; testicular tissue protein Li 155
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP62136
  • Protein Name
    Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
  • Scientific Description
    The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • KIF18A interacts with PPP1CA to promote the malignant development of glioblastoma.
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  • Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling. Noguchi Y et al., 2021 Jul 23, iScience
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  • Carfilzomib induces leukaemia cell apoptosis via inhibiting ELK1/KIAA1524 (Elk-1/CIP2A) and activating PP2A not related to proteasome inhibition. Liu CY et al., 2017 Jun, Br J Haematol
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  • Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Wei R et al., 2011 Oct, Mol Biol Cell
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