IHC-P analysis of human kidney tissue using GTX15548 Presenilin 2 antibody [APS 21]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:100
![WB analysis of 25 ug of SH-SY5Y (lane 1), human brain (lane 2) and PC12 (lane 3) using GTX15548 Presenilin 2 antibody [APS 21]. Dilution : 1:200](https://www.genetex.com/upload/website/prouct_img/normal/GTX15548/GTX15548_1495_WB_w_23060620_115.webp "WB analysis of 25 ug of SH-SY5Y (lane 1), human brain (lane 2) and PC12 (lane 3) using GTX15548 Presenilin 2 antibody [APS 21]. Dilution : 1:200")
![ICC/IF analysis of A2058 Cells using GTX15548 Presenilin 2 antibody [APS 21]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15548/GTX15548_259_ICC-IF_w_23060620_351.webp "ICC/IF analysis of A2058 Cells using GTX15548 Presenilin 2 antibody [APS 21]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC")
![ICC/IF analysis of HeLa cells using GTX15548 Presenilin 2 antibody [APS 21]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15548/GTX15548_260_ICC-IF_w_23060620_893.webp "ICC/IF analysis of HeLa cells using GTX15548 Presenilin 2 antibody [APS 21]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC")
![ICC/IF analysis of NCI-H460 Cells using GTX15548 Presenilin 2 antibody [APS 21]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15548/GTX15548_261_ICC-IF_w_23060620_497.webp "ICC/IF analysis of NCI-H460 Cells using GTX15548 Presenilin 2 antibody [APS 21]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC")
IHC-P analysis of human kidney tissue using GTX15548 Presenilin 2 antibody [APS 21]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:100
Presenilin 2 antibody [APS 21]
GTX15548
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPSEN2
Overview
- SupplierGeneTex
- Product NamePresenilin 2 antibody [APS 21]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:100-1:1000. ICC/IF: 0.75 microg/ml. IHC-P: 1:100. ELISA: 4.5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAPS 21
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID5664
- Target namePSEN2
- Target descriptionpresenilin 2
- Target synonymsAD3L; AD3LP; AD4; AD5; Alzheimer disease 4; CMD1V; E5-1; presenilin-2; PS2; PS-2; STM2; STM-2
- HostMouse
- IsotypeIgG1
- Protein IDP49810
- Protein NamePresenilin-2
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
Datasheet
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