Presenilin 2 antibody

GeneTex

Presenilin 2 antibody

9

ELISA: 1/1000 - 1/4000. IHC: Use at an assay dependent dilution. WB: 1/1000 - 1/4000. Predicted molecular weight: 54 kDa. To minimize background staining, we suggest using higher content of detergent (Tween-20) in dilutions of the antibody and washing. Optimal dilutions/concentrations should be determined by the end user.

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PSEN2

presenilin 2

AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; CMD1V; E5-1; presenilin-2; PS2; PS-2; STM2; STM-2

Chicken

IgY

Presenilin-2

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203