IHC-P analysis of human kidney tissue using GTX15549 Presenilin 2 antibody [APS 26]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:20
![WB analysis of 25 ug of human brain (lane 1) and L929 (lane 2) using GTX15549 Presenilin 2 antibody [APS 26]. Dilution : 1:200](https://www.genetex.com/upload/website/prouct_img/normal/GTX15549/GTX15549_1496_WB_w_23060620_140.webp "WB analysis of 25 ug of human brain (lane 1) and L929 (lane 2) using GTX15549 Presenilin 2 antibody [APS 26]. Dilution : 1:200")
![ICC/IF analysis of mouse fibroblasts using GTX15549 Presenilin 2 antibody [APS 26].](https://www.genetex.com/upload/website/prouct_img/normal/GTX15549/GTX15549_262_ICC-IF_w_23060620_536.webp "ICC/IF analysis of mouse fibroblasts using GTX15549 Presenilin 2 antibody [APS 26].")
![ICC/IF analysis of A2058 Cells using GTX15549 Presenilin 2 antibody [APS 26]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:20 overnight at 4oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15549/GTX15549_263_ICC-IF_w_23060620_815.webp "ICC/IF analysis of A2058 Cells using GTX15549 Presenilin 2 antibody [APS 26]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:20 overnight at 4oC")
![ICC/IF analysis of HeLa cells using GTX15549 Presenilin 2 antibody [APS 26]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:20 overnight at 4oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15549/GTX15549_264_ICC-IF_w_23060620_395.webp "ICC/IF analysis of HeLa cells using GTX15549 Presenilin 2 antibody [APS 26]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:20 overnight at 4oC")
IHC-P analysis of human kidney tissue using GTX15549 Presenilin 2 antibody [APS 26]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:20
Presenilin 2 antibody [APS 26]
GTX15549
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Primate, Rat
TargetPSEN2
Overview
- SupplierGeneTex
- Product NamePresenilin 2 antibody [APS 26]
- Delivery Days Customer9
- Antibody SpecificityNo cross-reactivity is seen with presenilin 1. This antibody detects an ~20 kDa protein representing PS2 CT (C-terminal fragment) and the ~45 kDa full-length PS2 from transfected COS-7 cells.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAPS 26
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID5664
- Target namePSEN2
- Target descriptionpresenilin 2
- Target synonymsAD3L; AD3LP; AD4; AD5; Alzheimer disease 4; CMD1V; E5-1; presenilin-2; PS2; PS-2; STM2; STM-2
- HostMouse
- IsotypeIgG1
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse, Primate, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203